DR CNRS
Equipe MAOS
emmanuel.barbeau@cnrs.fr
Tél : 05.62.74.61.55
Research Interests
I’m a CNRS director of research (PhD, HDR) and work in the CerCo in the DYNAMO team. I study declarative memory in the human using neuropsychological, neuroimaging and electrophysiological approaches. Lately I got interested in various aspects of epilepsy. Some key words that could define my work are: semantic and episodic memory; recognition memory; the visual ventral stream; hippocampus; perirhinal cortex; medial temporal lobes; Alzheimer’s disease; Epilepsy; intracerebral recordings; single-unit recording; tetrodes; high frequency oscillations, etc.
• I co-head a Master’s program in Neuropsychology and Clinical Neuroscience (website here).
• I’m also co-founder of Avrio MedTech. Avrio MedTech develops diagnostic tools for intracranial EEG (iEEG) procedures, leveraging existing and new biomarkers such as high-frequency oscillations (HFO) (website here).
Publications: last 10 years
1. Kopal J, Hlinka J, Despouy E, Valton L, Denuelle M, Sol JC, Curot J, Barbeau EJ. Large-scale network dynamics underlying the first few hundred milliseconds after stimulus presentation. An investigation of visual recognition memory using iEEG. Human Brain Mapping, In press.
2. Servais A, Barbeau EJ, Hurter, C. A new protocol to study mind-wandering for air traffic controllers: A pilot study. Aviation Psychology and Applied Human Factors. In press.
3. Servais A, Hurter C, Barbeau EJ. Attentional switch to memory: an early and critical phase of the complex cognitive cascade allowing autobiographical memory retrieval. Psychonomic Bulletin & Review, in press. DOI: 10.3758/s13423-023-02270-w
4. Curot J, Barbeau EJ, Despouy E, Denuelle M, Sol JC, Lotterie JA, Valton L, Peyrache A. (2023). Local neuronal excitation and global inhibition during epileptic fast ripples in humans. Brain, 146(2):561-575. DOI: 10.1093/brain/awac319
5. Benaiteau M, Valton L, Gardy L, Denuelle M, Debs R, Wucher V, Rulquin F, Barbeau EJ, Bonneville F, Pariente J, Curot J. (2023). Specific Profiles of New-Onset (NOSE) vs Non-Inaugural (NISE) Status Epilepticus. Frontiers in Neurology. 14, 46. doi: 10.3389/fneur.2023.1101370.
6. Servais A, Hurter C, Barbeau EJ. (2022). Gaze direction as a facial cue of memory retrieval state. Frontiers in Psychology, 13:1063228. doi: 10.3389/fpsyg.2022.1063228
7. Cecchi R, Vinckier F, Hammer J, Marusic P, Nica A, Rheims S, Trebuchon A, Barbeau EJ, Denuelle M, Maillard L, Minotti L, Kahane P, Pessiglione M, Bastin J. (2022). Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice. Elife. 11:e72440. DOI: 10.7554/eLife.72440
8. Szabo AB, Cretin B, Gerard F, Curot J, Barbeau EJ, Pariente J, Dahan L, Valton L. (2022). Sleep: the tip of the iceberg in the bidirectional link between Alzheimer’s disease and epilepsy. Frontiers in Neurology, 13:836292. DOI: 10.3389/fneur.2022.836292
9. Lemesle B, Barbeau EJ, Rigal EM, Denuelle M, Valton L, Pariente J, Curot J. (2022). Hidden objective memory deficits behind subjective memory complaints in patients with temporal lobe epilepsy. Neurology, 98(8):e818-e828.DOI: 10.1212/WNL.0000000000013212
10. Jonin PY, Duché Q, Bannier E, Corouge I, Ferré JC, Belliard S, Barillot C, Barbeau EJ. (2022). Building memories on prior knowledge: behavioral and fMRI evidence of impairment in early Alzheimer’s disease. Neurobiology of Aging,110:1-12. DOI: 10.1016/j.neurobiolaging.2021.10.013
11. Joubert S, Gardy L, Didic M, Rouleau I, Barbeau EJ. (2021). A meta-analysis of semantic memory in Mild Cognitive Impairment. Neuropsychology review, 31(2):221-232. DOI: 10.1007/s11065-020-09453-5.
12. Curot J, Roux FE, Sol JC, Valton L, Pariente P, Barbeau EJ. (2020). Awake craniotomy and memory induction through electrical stimulation: Why are Penfield’s findings not replicated in the modern era? Neurosurgery, 87(2):E130-E137. DOI: 10.1093/neuros/nyz553
13. Despouy E, Curot J, Reddy L, Nowak LG, Deudon M, Sol JC, Lotterie JA, Denuelle M, Mazizh A, Bergaud C, Thorpe SJ, Valton L, Barbeau EJ. (2020). Recording local field potential and neuronal activity with tetrodes in epileptic patients. Journal of Neuroscience Methods, 341:108759. DOI: 10.1016/j.jneumeth.2020.108759
14. Despouy E, Curot J, DeudonM, GardyL, Denuelle M, SolJC, LotterieJA, ValtonL, Barbeau EJ. (2020). A fast visual recognition memory system in humans identified using intracerebral ERP. Cerebral Cortex, 30(5):2961-2971. DOI: 10.1093/cercor/bhz287
15. Rémy F, Vayssière N, Saint-Aubert L, Bacon-Macé N, Pariente J, Barbeau E, Fabre-Thorpe M. (2020). Age effects on the neural processing of briefly flashed incongruent natural scenes. Neuropsychologia, 136, 107264. 10.1016/j.neuropsychologia.2019.107264
16. Curot J, Barbeau EJ. (2020). Improving the Integrative Memory Model by integrating the temporal dynamics of memory. Behavioral and Brain Science, 42, e286. Invited commentary. DOI: 10.1017/S0140525X19001973
17. Curot J, Pariente J, Hupé JM, Mirabel H, Barbeau EJ. (2019). Déjà-vu and prescience in a case of severe episodic amnesia following bilateral hippocampal lesions. Memory, 6:1-16. DOI: 10.1080/09658211.2019.1673426
18. Bastin C, Delhaye E, Moulin C*, Barbeau EJ*. (2019). Novelty processing and memory impairment in Alzheimer’s disease: a review. Neuroscience and Biobehavioural Reviews, 100:237-249. *Contribution égale. Article de revue. https://doi.org/10.1016/j.neubiorev.2019.02.021
19. Jonin PY, Calia C, Muratot S, Belliard S, Barbeau, EJ Parra MA. (2019). Refining understanding of working memory buffers through the construct of binding: evidence from a single case informs theory and clinical practice. Cortex, 112:37-57. https://doi.org/10.1016/j.cortex.2018.08.011
20. Despouy E, Curot J, Denuelle M, Deudon M, Sol JC, Lotterie JA, Reddy L, Nowak LG, Pariente J, Thorpe SJ, Valton L, Barbeau EJ. (2019). Neuronal spiking activity highlights a gradient of epileptogenicity and complex interactions in human tuberous sclerosis lesions. Clinical Neurophysiology, 130(4):537-547. DOI: 10.1016/j.clinph.2018.12.0132
21. Pistono A, Busigny T, Jucla M, Cabirol A, Dinnat AL, Pariente J, Barbeau EJ. An analysis of famous person semantic memory in ageing. (2019). Experimental Aging Research, 45(1):74-93. DOI: 10.1080/0361073X.2018.1560118
22. Jonin PY, Besson G, Lajoie R, Pariente J, Belliard S, Barillot C, Barbeau EJ. (2018). Superior explicit memory despite severe developmental amnesia: in-depth case study and neural correlates. Hippocampus, 28(12):867-88.https://doi.org/10.1002/hipo.23010
23. Pergola G, Danet, L, Pitel AL, Carlesimo GA, Segobin S, Pariente, J, Suchan, B, Mitchell AS*, Barbeau EJ*. (2018). The regulatory role of the human mediodorsal thalamus, Trends in Cognitive Science, 22(11):1011-1025. *Contribution égale. https://doi.org/10.1016/j.tics.2018.08.006
24. Cauchoix M, Chow PKY, van Horik JO, Atance CM, Barbeau EJ, Barragan-Jason G, Bize P, Boussard A, Buechel SD, Cabirol A, Cauchard L, Claidière N, Dalesman S, Devaud JM, Didic M, Doligez B, Fagot J, Fichtel C, Henke-von der Malsburg J, Hermer E, Huber L, Huebner F, Kappeler PM, Klein S, Langbein J, Langley EJG, Lea SEG, Lihoreau M, Lovlie H, Matzel LD, Nakagawa S, Nawroth C, Oesterwind S, Sauce B, Smith E, Sorato E, Tebbich S, Wallis LJ, Whiteside MA, Wilkinson A, Chaine AS, Morand-Ferron J. (2018). The repeatability of cognitive performance: a meta-analysis. Philosophical Transactions B, 373(1756). https://doi.org/10.1098/rstb.2017.0281
25. Curot J, Valton L, Denuelle M, Vignal JP, Maillard L, Pariente J, Trebuchon A, Bartolomei F, Barbeau EJ. (2018). Déjà-rêvé: prior dreams induced by direct electrical brain stimulation. Brain stimulation, 11(4):875-885. https://doi.org/10.1016/j.brs.2018.02.016
26. Delhaye E, Bastin C, Moulin CJA, Besson G, Barbeau EJ. (2018). Bridging novelty and familiarity-based recognition memory as a single process: a matter of timing. Visual Cognition, 25:9-10, 949-955. https://doi.org/10.1080/13506285.2017.1362090
27. Larzabal C, Tramoni E, Muratot S, Thorpe SJ, Barbeau EJ. (2018). Extremely long-term memory and familiarity after 12 years. Cognition, 170:254-262. https://doi.org/10.1016/j.cognition.2017.10.009
28. Danet L, Pariente J, Eustache P, Raposo N, Sibon I, Albucher JF, Bonneville F, Peran P, Barbeau EJ. (2017). Medial thalamic stroke and its impact on familiarity and recollection. Elife, 6. pii: e28141. https://doi.org/10.7554/eLife.28141
29. Lacot E, Vautier S, Köhler S, Pariente J, Martin CJ, Puel M, Lotterie JA, Barbeau EJ. (2017). Familiarity and recollection vs representational models of medial temporal lobe structures: a single-case study. Neuropsychologia,104, 76-91. DOI: 10.1016/j.neuropsychologia.2017.07.032
30. Curot J, Busigny T, Valton L, Denuelle M, Vignal JP, Maillard L, Chauvel P, Pariente J, Trebuchon A, Bartolomei F, Barbeau EJ. (2017). Memory scrutinized through electrical brain stimulation: a review of 80 years of experiential phenomena. Neuroscience and Biobehavioral Reviews, 78,161–177. Article de revue. DOI : 10.1016/j.neubiorev.2017.04.018. Cet article a fait l’objet d’une communication de l’INSB : http://www.cnrs.fr/insb/recherche/parutions/articles2017/j-curot.html. https://doi.org/10.1016/j.neubiorev.2017.04.018
31. Barbeau EJ, Chauvel P, Moulin C, Regis J, Liégeois-Chauvel C. (2017). Hippocampus duality: memory and novelty detection are subserved by distinct mechanisms. Hippocampus, 27(4):405-416. Cet article a fait l’objet de la une de couverture d’Hippocampus.
32. Besson G, Barragan-Jason G, Thorpe SJ, Puma S, Ceccaldi M, Barbeau EJ. (2017). From face processing to face recognition: comparing three different processing levels. Cognition, 158, 33-43.
33. Vallet GT, Rouleau I, Benoit S, Langlois R, Barbeau E, Joubert S. (2016). Alzheimer’s Disease and Memory Strength: Graduate Decline of Memory Traces as a Function of their Strength. Journal of Clinical and Experimental Neuropsychology, 38(6):648-60.
34. Pistono A, Jucla M, Barbeau EJ, Saint-Aubert L, Kopke B, Puel M, Pariente J. (2016). Pauses correlate with episodic memory during discourse of patients with Mild Cognitive Impairment. Journal of Alzheimer’s Disease, 50(3), 687-98.https://doi.org/10.3233/JAD-150408
35. Dupierrix E, Hillairet de Boisferon A, Barbeau EJ, Pascalis O. (2015). Memory for complex visual objects but not for allocentric locations during the first year of life. International Journal of Behavioral Development, 39(4), 332-338.
36. Danet L, Barbeau EJ, Eustache P, Raposo N, Sibon I, Albucher JF, Bonneville F, Peran P, Pariente J. (2015). Implication of the mamillo-thalamic tract in the memory impairment of thalamic stroke patients. Neurology, 15;85(24):2107-15. https://doi.org/10.1212/WNL.0000000000002226
37. Barragan-Jason G, Cauchoix M, Barbeau EJ. (2015). The neural speed of familiar face recognition. Neuropsychologia, 75:390-401.
38. Rémy F, Vayssière N, Saint-Aubert L, Barbeau EJ, Pariente J. (2015). White matter disruption at the prodromal stage of Alzheimer’s disease: relationships with hippocampal atrophy and episodic memory performance. Neuroimage: clinical, 7: 482-92.
39. Besson G, Ceccaldi M, Tramoni E, Felician O, Didic M and Barbeau EJ. (2015). Fast, but not slow, familiarity is preserved in patients with amnestic Mild Cognitive Impairment. Cortex, 65: 36-49.
40. Busigny T, de Boissezon X, Puel M, Nespoulous JL, Barbeau EJ. (2015). Proper name anomia with preserved lexical and semantic knowledge after left anterior temporal lesion: a convergent effect. Cortex, 65: 1-18.
41. Condret V, Barragan-Jason G, Denuelle M, Curot J, Nespoulous JL, Valton L, Barbeau EJ. (2014). Characterization of proper name retrieval failures in temporal lobe epilepsy. Epilepsy Research, 108:1825-38.
42. Kaphan E, Barbeau EJ, Royere ML, Guedj E, Pelletier J, Ali Chérif A. (2014). Ganser-like syndrome after loss of psychic self-activation syndrome: psychogenic or organic? Archives of Clinical Neuropsychology, 29(7):715-23.
43. Busigny T, Pagès B, Barbeau EJ, Bled C, Montaut E, Raposo N, Albucher JF, Chollet F, Pariente J. (2014). A systematic study of topographical memory and posterior cerebral artery infarctions. Neurology, 83(11):996-1003.
44. Pages B, Planton M, Buys S, Lemesle B, Birmes P, Barbeau EJ, Maziero S, Cordier L, Cabot C, Puel M, Genestal M, Chollet F, Pariente J. (2014). Neuropsychological outcome after carbon monoxide exposure following a storm: a case-control study. BMC Neurology, 14:153.
45. Nemmi F, Saint-Aubert L, Adel D, Salabert AS, Pariente J, Barbeau EJ, Payoux P, Péran P. (2014). Insight on AV-45 binding in grey and white matter from histogram analysis: study on early Alzheimer’s disease and healthy subjects. European Journal of Nuclear Medicine and Molecular Imaging, 41(7):1408-18.
46. Saint-Aubert L, Nemmi F, Péran P, Barbeau EJ, Payoux P, Chollet F, Pariente J. (2014). Comparison between PET-template-based method and optimized cortical-MRI-based method for quantification of florbetapir (AV-45) uptake in vivo. European Journal of Nuclear Medicine and Molecular Imaging, 41(5):836-43.
47. Cauchoix M, Barragan-Jason G, Serre T*, Barbeau EJ*. (2014). The neural dynamics of face detection in the wild revealed by MVPA. Journal of Neuroscience, 34(3): 846-854. Contribution égale.
48. De Anna F, Didic M, Barbeau EJ, Mancini J, Felician O, Ceccaldi M. (2014). Increasing cognitive changes during follow-up in amnestic Mild Cognitive Impairment patients with impaired visual recognition memory. Neuropsychology, 28(1): 98-105.
49. Rémy F, Saint-Aubert L, Bacon-Macé N, Vayssière N, Barbeau EJ, Fabre-Thorpe M. (2013). Object recognition in congruent and incongruent natural scenes: a life span study. Vision research, 91:36-44.
50. Saint-Aubert L, Barbeau EJ, Péran P, Vervueren C, Mirabel H, Payoux P, Hitzel A, Bonneville F, Gramada R, Nemmi F, Vincent C, Puel M, Dechaumont S, Chollet F, Pariente J. (2013). Florbetapir-PET amyloid imaging in highly selected prodromal Alzheimer’s disease patients. Journal of European Nuclear Medecine and Molecular Imaging Research, 3(1):43.
51. Didic M, Felician O, Barbeau EJ, Mancini J, Latger-Florence C, Poncet M, Ceccaldi M. (2013). Impaired visual recognition memory predicts Alzheimer’s disease in amnestic MCI. Dementia and Geriatric Cognitive Disorders, 35, 291-299.
52. Barragan-Jason G, Besson G, Ceccaldi M, Barbeau EJ. (2013). Fast and Famous: Looking for the fastest speed at which a face can be recognized. Frontiers in Psychology, 4:100, doi:10.3389/fpsyg.2013.00100.
53. Condret V, Barbeau EJ, Matharan F, Le Goff M, Dartigues JF, Amieva H. (2013). Prevalence of proper name complaint and prediction for dementia in a population-based study of elders. Dementia and Geriatric Cognitive Disorders, 35, 313-321.
54. Saint-Aubert L, Payoux P, Hannequin D, Barbeau EJ, Campion D, Delisle MB, Tafani M, Viallard G, Péran P, Puel M, Chollet F, Demonet JF, Pariente J. (2013). MR, 18F-FDG and 18F-AV45 PET correlate with AD PSEN1 original phenotype. Alzheimer Disease & Associated Disorders, 27(1): 91-94.
(complete publications list here)
For the DMS48, a visual recognition memory test I’ve designed for the assessment of early Alzheimer’s disease, please see this link.