DYNAMO – Neural Dynamics of Memory and Object Processing.

Responsable: Leila Reddy

L’équipe DYNAMO adopte une approche multi-échelle pour aborder de manière exhaustive les fondements neuraux de la représentation des objets, de l’apprentissage, de la mémoire, et pour explorer ce qui se passe lorsque le code neural dysfonctionne (par exemple dans l’épilepsie). Nous abordons ces thèmes avec un éventail impressionnant de techniques, qui comprennent l’enregistrement in vitro sur tranche de cerveau humain, l’enregistrement de neurones isolés dans le cerveau humain, l’enregistrement du potentiel de champ local (LFP) et de l’EEG intracrânien (iEEG) dans le cerveau humain, la stimulation cérébrale intracrânienne chez les patients éveillés, l’IRM fonctionnelle, l’apprentissage comportemental chez les sujets sains et dans le vieillissement pathologique (par exemple, la maladie d’Alzheimer), la modélisation informatique et l’intelligence artificielle.

Thématiques:

Dynamique neuronale dans le cerveau
•(Emmanuel Barbeau, Jonathan Curot, Lionel Nowak, Leila Reddy)
La représentation des objets
•(Lionel Nowak, Leila Reddy)
Apprentissage et mémoire
•(Emmanuel Barbeau, Jonathan Curot, Leila Reddy, Simon Thorpe, Pier-Giorgio Zanone)
Les pathologies de la mémoire
•(Emmanuel Barbeau, Jonathan Curot, Marie Denuelle, Lionel Nowak, Luc Valton)

Chercheurs
Emmanuel Barbeau (DR2, CNRS)
Jonathan Curot (MCU-PH, CHU Purpan)
Marie Denuelle (PH,CHU Purpan)
Lionel Nowak (CRHC, CNRS)
Leila Reddy (DR2, CNRS)
Simon Thorpe (DRCE, CNRS)
Luc Valton (PH, CHU Purpan)
Pier-Giorgio Zanone (PRCE, UPS)

Chercheur associé

Christophe Hurter

ATER

Marie GLEIZES

Assistant CHU

Marina INUYTINA

Doctorants
Siwar BOUDEN

Aube DARVES-BORNOZ

Vincent DORNIER

Aditya KAR

Benoit MARCY

Cécile MERVEILLIE

Julie VIDAL

Publications représentatives :

  • Cruz T, Gleizes M, Balayssac S, Mornet E, Marsal G, Millán JL, Malet-Martino M, Nowak LG, Gilard V, Fonta C (2017) Identification of altered brain metabolites associated with TNAP activity in a mouse model of hypophosphatasia using untargeted NMR-based metabolomics analysis. J Neurochem 140: 919-940. https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.13950.
  • Curot, J., Valton, L., Denuelle, M., Vignal, J. P., Maillard, L., Pariente, J., Trébuchon, A., Bartolomei, F., & Barbeau, E. J. (2018). Déjà-rêvé: Prior dreams induced by direct electrical brain stimulation. Brain Stimulation, 11(4), 875–885. https://doi.org/10.1016/j.brs.2018.02.016
  • Curot, J., Busigny, T., Valton, L., Denuelle, M., Vignal, J.-P., Maillard, L., Chauvel, P., Pariente, J., Trebuchon, A., Bartolomei, F., & Barbeau, E. J. (2017). Memory scrutinized through electrical brain stimulation: A review of 80 years of experiential phenomena. Neuroscience and Biobehavioral Reviews, 78. https://doi.org/10.1016/j.neubiorev.2017.04.018
  • Despouy E, Curot J, Deudon M, Gardy L, Denuelle M, Sol JC, Lotterie JA, Valton L, Barbeau EJ. (2020). A fast visual recognition memory system in humans identified using intracerebral ERP. Cerebral Cortex, 30(5):2961-2971. https://doi.org/10.1093/cercor/bhz287
  • Despouy E, Curot J, Reddy L, Nowak LG, Deudon M, Sol JC, Lotterie JA, Denuelle M, Maziz A, Bergaud C, Thorpe SJ, Valton L, Barbeau EJ (2020) Recording local field potential and neuronal activity with tetrodes in epileptic patients. J Neurosci Methods 341:108759. doi: 10.1016/j.jneumeth.2020.108759.
  • Despouy, E., Curot, J., Denuelle, M., Deudon, M., Sol, J., Lotterie, J., Reddy, L., Nowak, L. G., Pariente, J., Thorpe, S. J., Valton, L., & Barbeau, E. J. (2019). Neuronal spiking activity highlights a gradient of epileptogenicity in human tuberous sclerosis lesions. Clinical Neurophysiology, 130(4), 537–547. https://doi.org/10.1016/j.clinph.2018.12.013
  • Hervault M., Huys R., Farrer C., Buisson J.C., & Zanone PG (2019) Cancelling discrete and stopping ongoing rhythmic movements: Do they involve the same process of motor inhibition? Human Movement Science, 64, 296-306. DOI: 10.1016/j.humov.2019.02.010
  • Huys, R., Kolodziej, A., Lagarde, J., Farrer, C., Darmana, R., & Zanone, P.G. (2018) Individual and dyadic rope turning as a window into social coordination. Human Movement Science, 58, 55-68.  DOI: 10.1016/j.humov.2017.12.015
  • Jonin PY, Besson G, Lajoie R, Pariente J, Belliard S, Barillot C, Barbeau EJ. (2018). Superior explicit memory despite severe developmental amnesia: in-depth case study and neural correlates. Hippocampus, 28(12):867-88. https://doi.org/10.1002/hipo.23010
  • Mozafari, M., Reddy, L., VanRullen, R. (2020). Reconstructing Natural Scenes from fMRI Patterns using BigBiGAN. IJCNN: International Joint Conference on Neural Networks, 2020, Glasgow, United Kingdom.
    https://arxiv.org/abs/2001.11761
  • Perrier SP, Gleizes M, Fonta C, Nowak LG (2019)  Effect of adenosine on short-term synaptic plasticity in mouse piriform cortex in vitro: adenosine acts as a high-pass filter. Physiol Rep. 2019 7: e13992. https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13992.
  • Reddy L., Self, M.W., et al., Theta-phase dependent neuronal coding during sequence learning in human single neurons. https://hal.archives-ouvertes.fr/hal-03001277v1
  • VanRullen, R., Reddy, L. (2019). Reconstructing Faces from fMRI Patterns using Deep Generative Neural Networks. Communications Biology. https://www.nature.com/articles/s42003-019-0438-y