DYNAMO – Neural Dynamics of Memory and Object Processing.

Head: Leila Reddy

The DYNAMO team takes a multi-scale approach to comprehensively address the neural underpinnings of object representations, learning, and memory, and explore what happens when the neuronal code goes awry (e.g., during epilepsy). We approach these themes with an impressive array of techniques, that include in vitro recordings in human brain slices, single neuron, local field potential (LFP), and intracranial EEG (iEEG) recordings in the human brain, intracranial brain stimulation in awake patients, fMRI, behavioral learning in healthy subjects and in pathological aging (e.g., Alzheimer’s disease), computational modeling, and advanced machine-learning methodology, including AI.

Research Themes:
Neuronal dynamics within and across brain areas
•(Emmanuel Barbeau, Jonathan Curot, Lionel Nowak, Leila Reddy)
Object representations
•(Lionel Nowak, Leila Reddy)
Learning, memory, recall
•(Emmanuel Barbeau, Jonathan Curot, Leila Reddy, Simon Thorpe, Pier-Giorgio Zanone)
Memory and pathologies
•(Emmanuel Barbeau, Jonathan Curot, Marie Denuelle, Lionel Nowak, Luc Valton)

Permanent research staff
Emmanuel Barbeau (DR2, CNRS)
Jonathan Curot (MCU-PH, CHU Purpan)
Marie Denuelle (PH,CHU Purpan)
Lionel Nowak (CRHC, CNRS)
Leila Reddy (CRCN, CNRS)
Simon Thorpe (DRCE, CNRS)
Luc Valton (PH,CHU Purpan)
Pier-Giorgio Zanone (PRCE, UPS)

Post-doctoral fellows

PhD students
Ludovic GARDY

Selected Publications:

  • Cruz T, Gleizes M, Balayssac S, Mornet E, Marsal G, Millán JL, Malet-Martino M, Nowak LG, Gilard V, Fonta C (2017) Identification of altered brain metabolites associated with TNAP activity in a mouse model of hypophosphatasia using untargeted NMR-based metabolomics analysis. J Neurochem 140: 919-940. https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.13950. 
  • Curot, J., Valton, L., Denuelle, M., Vignal, J. P., Maillard, L., Pariente, J., Trébuchon, A., Bartolomei, F., & Barbeau, E. J. (2018). Déjà-rêvé: Prior dreams induced by direct electrical brain stimulation. Brain Stimulation, 11(4), 875–885. https://doi.org/10.1016/j.brs.2018.02.016
  • Curot, J., Busigny, T., Valton, L., Denuelle, M., Vignal, J.-P., Maillard, L., Chauvel, P., Pariente, J., Trebuchon, A., Bartolomei, F., & Barbeau, E. J. (2017). Memory scrutinized through electrical brain stimulation: A review of 80 years of experiential phenomena. Neuroscience and Biobehavioral Reviews, 78. https://doi.org/10.1016/j.neubiorev.2017.04.018
  • Despouy E, Curot J, Deudon M, Gardy L, Denuelle M, Sol JC, Lotterie JA, Valton L, Barbeau EJ. (2020). A fast visual recognition memory system in humans identified using intracerebral ERP. Cerebral Cortex, 30(5):2961-2971. https://doi.org/10.1093/cercor/bhz287
  • Despouy E, Curot J, Reddy L, Nowak LG, Deudon M, Sol JC, Lotterie JA, Denuelle M, Maziz A, Bergaud C, Thorpe SJ, Valton L, Barbeau EJ (2020) Recording local field potential and neuronal activity with tetrodes in epileptic patients. J Neurosci Methods 341:108759. doi: 10.1016/j.jneumeth.2020.108759.
  • Despouy, E., Curot, J., Denuelle, M., Deudon, M., Sol, J., Lotterie, J., Reddy, L., Nowak, L. G., Pariente, J., Thorpe, S. J., Valton, L., & Barbeau, E. J. (2019). Neuronal spiking activity highlights a gradient of epileptogenicity in human tuberous sclerosis lesions. Clinical Neurophysiology, 130(4), 537–547. https://doi.org/10.1016/j.clinph.2018.12.013
  • Hervault M., Huys R., Farrer C., Buisson J.C., & Zanone PG (2019) Cancelling discrete and stopping ongoing rhythmic movements: Do they involve the same process of motor inhibition? Human Movement Science, 64, 296-306. DOI: 10.1016/j.humov.2019.02.010
  • Huys, R., Kolodziej, A., Lagarde, J., Farrer, C., Darmana, R., & Zanone, P.G. (2018) Individual and dyadic rope turning as a window into social coordination. Human Movement Science, 58, 55-68.  DOI: 10.1016/j.humov.2017.12.015
  • Jonin PY, Besson G, Lajoie R, Pariente J, Belliard S, Barillot C, Barbeau EJ. (2018). Superior explicit memory despite severe developmental amnesia: in-depth case study and neural correlates. Hippocampus, 28(12):867-88. https://doi.org/10.1002/hipo.23010
  • Mozafari, M., Reddy, L., VanRullen, R. (2020). Reconstructing Natural Scenes from fMRI Patterns using BigBiGAN. IJCNN: International Joint Conference on Neural Networks, 2020, Glasgow, United Kingdom.
  • Perrier SP, Gleizes M, Fonta C, Nowak LG (2019)  Effect of adenosine on short-term synaptic plasticity in mouse piriform cortex in vitro: adenosine acts as a high-pass filter. Physiol Rep. 2019 7: e13992. https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13992.
  • Reddy L., Self, M.W., et al., Theta-phase dependent neuronal coding during sequence learning in human single neurons. https://hal.archives-ouvertes.fr/hal-03001277v1
  • VanRullen, R., Reddy, L. (2019). Reconstructing Faces from fMRI Patterns using Deep Generative Neural Networks. Communications Biology. https://www.nature.com/articles/s42003-019-0438-y