Presentation

Team Dynamo explores the brain mechanisms involved in learning, memory, and object recognition, with strong focus on clinical applications in epilepsy. We combine recordings of single neurons, local field potentials, and intracranial EEG in epileptic patients with in vitro studies in mice, as well as fMRI, computational modelling, and AI. This multiscale strategy—from cells to networks—drives new insights into cognition and its alteration in epilepsy, strengthened by our close partnership with the Epilepsy Unit at Purpan Hospital.

Projects

Publications (selection)

• Dallmer-Zerbe I, et al. (2025). Pro-ictal, rather than pre-ictal, brain state marked by global critical slowing and local gamma power increase. Clinical Neurophysiology.
• Curot J, et al. (2025). Complex memories induced by intracranial electrical brain stimulation are related to complex patterns of functional connectivity. Cortex.
• Segobin S, et al. (2024). A roadmap towards standardized neuroimaging approaches for human thalamic nuclei. Nature Reviews in Neuroscience.
• Curot J, et al. (2023). Local neuronal excitation and global inhibition during epileptic fast ripples in humans. Brain.
• Reddy L, et al. (2021). Theta-phase dependent neuronal coding during sequence learning in human single neurons. Nature Communications.
• Despouy E, et al. (2020). A fast visual recognition memory system in humans identified using intracerebral ERP. Cerebral Cortex.
• Despouy E, et al. (2020). Recording local field potential and neuronal activity with tetrodes in epileptic patients. Journal of Neuroscience Methods.

Funding